Yeast Genetics; Post-Transcriptional Processing
The department maintains extensive expertise in yeast genetics and molecular biology. Studies focus on mechanisms involved in homologous recombination and post-transcriptional processing of premessenger RNAs. Research also includes the development and applications of RNA aptamers regulating diverse processes ranging from pre-mRNA splicing to receptor-mediated delivery of small interfering RNAs (siRNAs) to treat cancer and viral infections.

Epigenetics
Defining the epigenetic mechanisms regulating gene expression is vital to understanding both normal development and carcinogenesis. Investigative efforts include determining mechanisms of genetic imprinting and the role of small RNAs in heterochromatin formation. Research on the function of small RNAs is an important program in the department. There is also strong emphasis on how micro RNA functions as a post-transcriptional regulator of gene expression. Several laboratories are exploring therapeutic applications of RNA interference.

Biochemistry of DNA Damage and Repair
Understanding how DNA is damaged, both by mutagens and by treatments such as chemotherapy and radiotherapy, and the mechanisms governing DNA repair or the failure thereof, are essential to progress in developing better prevention and treatment strategies for a variety of cancers.

ARID Transcription Factors
This class of DNA-binding proteins is associated with regulation of fat metabolism, a finding that may lead to a better understanding of both carcinogenesis and weight loss.

Immune System Gene Regulation
The function and regulation of immune system genes greatly affects susceptibility to cancer and viral infection.