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 Adult T Cell Leukemia/Lymphoma (ATLL)

About Adult T Cell Leukemia/Lymphoma (ATLL)
Adult T cell leukemia/lymphoma (ATLL) is a rare type of lymphoid leukemia in which T cells are the abnormal leukemic cells, rather than the B cells found in most lymphoid leukemias. ATLL is thought to be almost exclusively caused by infection with a retrovirus called human T cell lymphotropic virus (HTLV-1). ATLL may exist in both acute and chronic forms.  The acute form progresses rapidly and has a poorer prognosis. It also has a smoldering form, in which the disease is more stable than the chronic form, and a lymphoma form, where the lymph nodes are involved to a greater extent than the blood.

Symptoms

  • Weakness or feeling tired
  • Easy bruising or bleeding
  • Recurrent infections
  • Hypercalcemia (high blood calcium)
  • Unusual skin lesions or rashes (leukemia cutis)
  • Rheumatic-like symptoms
Risk Factors

Exposure to the HTLV-1 virus. The virus is more prevalent in Japan, the Caribbean, some parts of Central and South America, and the southeastern United States. Infection may result from:

  • Transfusions of blood or blood products
  • Intravenous drug use (sharing needles)
  • Sexual transmission (unprotected sex, particularly with multiple partners)

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