Pioneers in the field of brain tumor research and treatment, City of Hope takes an aggressive approach to fighting the disease.

We use the world’s most advanced surgical techniques, superior radiation technologies and novel chemotherapies and immunotherapies to stop the growth and spread of brain tumors.  The close collaboration of our researchers and physicians – many of whom are renowned for their work – provide patients with brain tumors the most positive outcomes possible.

08096
P.I.: Nayana Vora, M.D.   
Title: RTOG 0614: A Randozmied, Phase III, Double- Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy

08070
P.I.: Jana Portnow, M.D.   
Title: BIBW 2992 With or Without Daily Temozolomide in the Treatment of Patients with Recurrent Malignant Glioma

07107
P.I.: Jana Portnow, M.D.   
Title: A Phase IIa Study of ADV-TK + Valacyclovir Gene Therapy in Combination with Standard Radiation Therapy for Malignant Gliomas

07064
P.I.: Jana Portnow, M.D.   
Title: A Phase I Dose Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacokinetics and Neuropharmacodynamics of Temsirolimus with and without Temozolomide in Patients with Primary or Metastatic Brain Tumors

07058
P.I.: Jana Portnow, M.D.  
Title: A Phase I Study of the Combination of Radiation Therapy (RT), Arsenic Trioxide (ATO) and Temozolomide (TMZ) in Patients with Newly-Diagnosed Glioblastoma Multiforme (GBM)

06222
P.I.: Jana Portnow, M.D.   
Title: A Phase Ib Study of ADV-TK + Valacyclovir Gene Therapy in Combination with Standard Radiation Therapy for Malignant Gliomas

06118
P.I.: Jana Portnow, M.D.   
Title: A Pharmacokinetic and Pharmacogenomic Study of Patients with High-Grade Gliomas Receiving Daily Radiation Therapy and Temozolomide

04032
P.I.: Jana Portnow, M.D.   
Title: A Phase I Study of Bortezomib and Temozolomide in Patients with Refractory Solid Tumors